DataDome can be used with any major CDN. The module is able to identify the real client IP that actually requests the page, and considers all IP ranges used by CDN service providers as Trusted Proxy.
Depending on your CDN, some configuration may be required.
The default Akamai configuration works seamlessly with the DataDome module, as it forwards all required information to the Origin.
If you are using Amazon CloudFront, on the other hand, you need to configure it to forward required information to the Origin.